Publications
News
_______________________________________________________________
BrainVectors publications have be done during all stages of the project according to the workplan and, namely, the list of deliverables. Articles about results and achievements of the BrainVectors project and potential technology transfer will be published in scientific journals and other dissemination media from 2013 to 2017.
2013
UniRM, UAB and CNRS
1.
Differentiated Neuroprogenitor Cells Incubated withHuman or Canine Adenovirus, or Lentiviral Vectors HaveDistinct Transcriptome Profiles Stefania Piersanti, Letizia Astrologo, Valerio Licursi, Rossella Costa, Enrica Roncaglia, Aurelie Gennetier, Sandy Ibanes, Miguel Chillon, Rodolfo Negri, Enrico Tagliafico, Eric J. Kremer, Isabella Saggio PLOS ONE July 2013 | Volume 8 | Issue 7 | e69808 (download the pdf)
2014
UAB
2.
Intrathecal administration of IGF-I by AAVrh10 improves sensory and motor deficits in a mouse model of diabetic neuropathy Judit Homs, Gemma Pagès, Lorena Ariza, Caty Casas, Miguel Chillón, Xavier Navarro and Assumpció Bosch Molecular Therapy — Methods & Clinical Development (2014) 1, 7; doi:10.1038/mtm.2013.7; 15 January 2014 (download the pdf)
UAB and CNRS
3.
Central Nervous System Delivery of Helper-Dependent Canine Adenovirus Corrects Neuropathology and Behavior in Mucopolysaccharidosis Type VII Mice Lorena Ariza,Lydia Gimenez-Llort, Aurelie Cubizolle, Gemma Pages, Belen Garcıa-Lareu, Nicolas Serratrice, Dan Cots,Rosemary Thwaite, Miguel Chillon, Eric J. Kremer, and Assumpcio Bosch HUMAN GENE THERAPY 25:199–211, March 2014 (download the pdf)
UniRM, UAB, CNRS and IBET
4.
Modeling human neural functionality in vitro: three-dimensional culture for dopaminergic differentiation. Simão D, Pinto C, Piersanti S, Weston A, Peddie CJ, Bastos AE, Licursi V, Schwarz SC, Collinson LM, Salinas S, Serra M, Teixeira AP, Saggio I, Lima PA, Kremer EJ, Schiavo G, Brito C, Alves PM. Tissue Eng Part A. 2015 Feb;21(3-4): 654-68. doi: 10.1089/ten.TEA.2014.0079. Epub 2014 Nov 11 (download the pdf)
UAB
5.
AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy R Thwaite1, G Pagès, M Chillón and A Bosch Gene Therapy, 20 November 2014; doi:10.1038 / gt.2014.103 (download the pdf)
2015
CNRS and IBET
6.
Impact of adenovirus life cycle progression on the generation of canine helper-dependent vectors. Fernandes P, Simão D, Guerreiro MR, Kremer EJ, Coroadinha AS, Alves PM. Gene Ther. 2015 Jan;22(1): 40-9 (download the pdf)
CNRS
7.
Adenovirus tales: from the cell surface to the nuclear pore complex. Kremer EJ, Nemerow GR. PLoS Pathog. 2015 Jun 4; 11(6): e1004821 (download the pdf)
IBET and CNRS
8.
Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation.Fernandes P, Almeida AI, Kremer EJ, Alves PM, Coroadinha AS.Sci Rep. 2015 Mar 16; 5: 9135. doi: 10.1038/srep09135. PubMed PMID: 25774853; PubMed Central PMCID: PMC4360735. (download the pdf)
IBET
9.
Production of canine adenovirus type 2 in serum-free suspension cultures of MDCK cells.Castro R, Fernandes P, Laske T, Sousa MF, Genzel Y, Scharfenberg K, Alves PM, Coroadinha AS.Appl Microbiol Biotechnol. 2015 Sep; 99 (17): 7059-68. doi: 10.1007/s00253-015-6636-8. PubMed PMID: 25994255.
UniRM, CNRS and IBET
10.
Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups Piersanti S, Burla R, Licursi V, Brito C, La Torre M, Alves PM, Simao D, Mottini C, Salinas S, Negri R, Tagliafico E, Kremer EJ, Saggio I.- PLoS One. 2015; 10(7): e0133607. Published online 2015 Jul 24. doi: 10.1371/journal.pone.0133607 (download the pdf)
11. 11. Modelling human neural functionality in vitro: 3D culture for dopaminergic differentiation Simão D, Pinto C, Piersanti S, Weston A, Peddie CJ, Bastos AEP, Licursi V, Schwarz SC, Collison LM, Salinas S, Serra M, Teixeira AP, Saggio I, Lima PA, Kremer EJ, Schiavo G, Brito C, Alves PM 2015, Tissue Engineering – Part A 21, 654-68.
CNRS and IBET
12.
The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry. Loustalot F, Kremer EJ, Salinas S. J Virol. 2015 Sep; 89(18): 9417-26 (download the pdf)
CNRS
13.
CAV-2-why a canine virus is a neurobiologist's best friend. Junyent F, Kremer EJ. Curr Opin Pharmacol. 2015 Oct; 24: 86-93 (download the pdf)
UAB and CNRS
14.
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression Anna Massó, Angela Sánchez, Lydia Gimenez-Llort, Jose Miguel Lizcano1, Manuel Cañete, Belen García, Virginia Torres-Lista, Meritxell Puig, Assumpció Bosch, Miguel Chillon PLOS ONE | DOI: 10.1371 / journal.pone.0143623 November 24, 2015 (download the pdf)
2016
CNRS
15.
Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector. Li Y, Hickey L, Perrins R, Werlen E, Patel AK, Hirschberg S, Jones MW, Salinas S, Kremer EJ, Pickering AE. Brain Res. 2016 Feb 19. pii: S0006-8993(16) 30082-8 (download the pdf)
CNRS, UniRM and IBET
16.
Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model. Simão D, Pinto C, Fernandes P, Peddie CJ, Piersanti S, Collinson LM, Salinas S, Saggio I, Schiavo G, Kremer EJ, Brito C, Alves PM. Gene Ther. 2016 Jan;23 (1): 86-94. doi: 10.1038/gt.2015.75. Epub 2015 Aug 20 (download the pdf)
ULUND
17.
Regulated Gene Therapy. Breger L, Wettergren EE, Quintino L, Lundberg C. Methods Mol Biol. 2016; 1382:57-66. doi: 10.1007/978-1-4939-3271-9_4 (download the pdf)
ULB, AMC, ULUND and CHUV
18.
A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub- antimicrobial doxycycline doses. Chtarto A, Humbert-Claude M, Bockstael O, Das AT, Boutry S, Breger L, Barroso-Chinea P, Klaver B, Melas C, González-Hernández T, Müller R, DeWitte O, Levivier M, Lundberg C, Berkhout B, Tenenbaum L . (2016) Mol.Ther.Methods and Clinical Developments. In press (download the pdf)
CHUV and ULB
19.
Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system Barroso-Chinea P., Cruz-Muros I., Afonso-Oramas D., Castro-Hernández J., Salas-Hernández J., Chtarto A., Luis-Ravelo D., Humbert-Claude M., Tenenbaum L. and González-Hernández T. (2016). Neurobiol. Dis. 88 : 44–54. (download the pdf)
CHUV and AMC
20.
Tet-On systems for doxycycline-inducible gene expressionDas A.T., Tenenbaum L., and Berkhout B. (2016) Curr Gene Ther. 16:156-67. (download the pdf)
CHUV and FIRALIS
21.
Tollip, an early regulator of the acute inflammatory response in the substantia nigra. Humbert-Claude M, Duc D, Dwir D, Thieren L, Sandström von Tobel J, Begka C, Legueux F, Velin D, Maillard MH, Do KQ, Monnet-Tschudi F, Tenenbaum L.(2016). J Neuroinflammation: 13(1):303
EASCO
22.
Proceedings from the EMBO Workshop: “Modern DNA Concepts and Tools for Safe Gene Transfer and Modification” Merten O.-W., Mezzina M. and Fisson S. Current Gene Therapy, 2016, Vol. 16, No. 3 153 (download the pdf)
2017
FIMA
23. Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System Diego Pignataro1, Diego Sucunza1, Lucia Vanrell, Esperanza Lopez-Franco2, Iria G. Dopeso-Reyes, Africa Vales, Mirja Hommel, Alberto J. Rico2, 3, 4, Jose L. Lanciego and Gloria Gonzalez-Aseguinolaza 2017 in Frontiers in Neuroanatomy February 2017 | Volume 11 | Article 2 (download the pdf)
CHUV
24. Glial cell line-Derived Neurotrophic Factor gene delivery in Parkinson’s disease: a delicate balance between neuroprotection, trophic effects and unwanted compensatory mechanisms.Tenenbaum L, Humbert-Claude M. (2017) Front. Neuroanat.. 2017 Apr 10;11:29. doi: 10.3389/fnana.2017.00029 (download the pdf)